Bipolar disorder
Also known as: bipolar I · bipolar II · mania
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No APA guideline indexed for this condition yet.
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Bipolar disorder: assessment and management
NICE (UK) · 2014 · CG185
UK national guidance on recognising, assessing and managing bipolar disorder in children, young people and adults, spanning bipolar I, bipolar II, mixed affective and rapid-cycling presentations. Originally issued in 2014 and revised since; the most recent revision (September 2025) incorporated updated medicines-regulator safety advice on valproate use in men.
US vs EU key differences
No curated US/EU comparison yet for this disease.
What changed recently
- EUCG38 (2006) → CG1852014-09-24
CG185 updates every section of the 2006 CG38 guideline, and following a 2011 network meta-analysis narrows first-line treatment of acute mania to antipsychotics such as haloperidol, olanzapine, quetiapine or risperidone, demoting the wider range of options including valproate that CG38 had listed alongside them. It also bars valproate in girls and women of childbearing potential and keeps the prohibition on antidepressant monotherapy, requiring an antipsychotic if mania or hypomania emerges on an antidepressant.
source ↗curation confidence 90%
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