Nephrotic syndrome
Also known as: FSGS · membranous nephropathy · minimal change disease
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KDIGO 2025 Clinical Practice Guideline for the Management of Nephrotic Syndrome in Children
KDIGO · 2025
This guideline addresses steroid-sensitive and steroid-resistant nephrotic syndrome in children, including when to biopsy, when to pursue genetic testing, and how to sequence glucocorticoids and steroid-sparing agents. KDIGO presents it as replacing Chapter 4 of the 2021 Glomerular Diseases guideline.
- KDIGO states this guideline updates Chapter 4 of the 2021 Glomerular Diseases guideline and was published online in April 2025. source
- Per KDIGO, the update supports shorter initial glucocorticoid courses and drops the former first-line versus alternative distinction among steroid-sparing agents. source
KDIGO 2025 Clinical Practice Guideline for the Management of Nephrotic Syndrome in Children
KDIGO · 2025
This guideline addresses steroid-sensitive and steroid-resistant nephrotic syndrome in children, including when to biopsy, when to pursue genetic testing, and how to sequence glucocorticoids and steroid-sparing agents. KDIGO presents it as replacing Chapter 4 of the 2021 Glomerular Diseases guideline.
- KDIGO states this guideline updates Chapter 4 of the 2021 Glomerular Diseases guideline and was published online in April 2025. source
- Per KDIGO, the update supports shorter initial glucocorticoid courses and drops the former first-line versus alternative distinction among steroid-sparing agents. source
US vs EU key differences
No curated US/EU comparison yet for this disease.
What changed recently
- GLOBAL2021 (Chapter 4 of the KDIGO Glomerular Diseases guideline) → 20252025-04-01
This guideline replaces Chapter 4 of the 2021 KDIGO glomerular diseases guideline, with most changes affecting treatment. It tightened the definition of infrequently relapsing disease from fewer than four to fewer than three relapses in a 12-month period and aligned its clinical definitions with the International Pediatric Nephrology Association guideline.
source ↗curation confidence 90%
See the full update feed for changes across every system.