Primary immunodeficiency
Also known as: common variable immunodeficiency · CVID · inborn errors of immunity · PID
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2025 Inborn errors of immunity practice parameter
AAAAI/ACAAI Joint Task Force on Practice Parameters, with the Clinical Immunology Society (CIS) · 2026 · 2025 practice parameter (published 2026)
The current US practice parameter on inborn errors of immunity (the term now used in place of primary immunodeficiency), issued jointly by the Joint Task Force on Practice Parameters with AAAAI, ACAAI and the Clinical Immunology Society. It reflects developments since the 2015 parameter, including genetic testing for diagnosis and treatment selection, newborn screening for severe T-cell lymphopenia, and targeted or precision therapies, and covers management topics such as immunoglobulin replacement, antibiotic prophylaxis, haematopoietic stem cell transplantation and quality-of-life assessment.
- AAAAI lists this as the current inborn errors of immunity practice parameter, dated April 2026, replacing the 2015 primary immunodeficiency parameter. source
- Developed jointly with the Clinical Immunology Society in addition to AAAAI and ACAAI. source
- The full text is hosted as a PDF on the AAAAI site. source
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US vs EU key differences
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What changed recently
- US2015 → 2025 practice parameter2026-04-01
The 2025 parameter abandons the previous edition's structure of working through individual genetic entities and instead organises recommendations into a diagnosis part and a management part. Diagnosis now covers newborn screening for severe combined immunodeficiency, genetic testing and comorbidity surveillance, while management addresses immunoglobulin replacement, antibiotic prophylaxis, haematopoietic stem cell transplantation, precision medicine and quality-of-life assessment.
source ↗curation confidence 90%
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