Thrombophilia
Also known as: antiphospholipid syndrome · APS · factor V Leiden · hypercoagulable state
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American Society of Hematology 2023 guidelines for management of venous thromboembolism: thrombophilia testing
American Society of Hematology (ASH) · 2023
A guideline devoted specifically to when thrombophilia testing does or does not change management. It works through clinical scenarios such as venous thromboembolism at typical and unusual sites, asymptomatic relatives of affected patients, people considering hormonal therapy, pregnancy, and cancer, and states where testing is not advised.
- Contains 23 recommendations covering testing in symptomatic venous thromboembolism, unusual-site thrombosis, asymptomatic family members, hormonal therapy, pregnancy and cancer. source
- Includes a strong recommendation against population-level thrombophilia screening before starting combined oral contraceptives. source
- Developed with GRADE methodology; the panel notes that nearly all recommendations rest on very low certainty evidence. Published in Blood Advances 2023, chaired by Saskia Middeldorp. source
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